Transaminase of Brain (I)
نویسندگان
چکیده
منابع مشابه
Effect of hydroxymethylpyrimidine on brain transaminase and glutamic decarboxylase.
It has been shown that 4-desoxypyridoxine (1, 2), incites seizures (3) and vita min B6-deficient states (3-6) in animals, but INAH (1) also has the property of inducing running fits (7, 8, 9) and vitamin B6 deficiency (10-13) and of inhibiting the enzymes related to vitamin B6 (14-20). The results of Makino and Aramaki (21-25), Kooka (26) and Miyake (27) show that 2-methyl-4-amino5-hydroxymethy...
متن کاملEffects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats
Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this en...
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Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is change...
متن کاملGlutamic Aspartic Transaminase
Aspartate and glutamate react instantaneously with the pyridoxal form of the pig heart glutamic aspartic transaminase (1) to yield the corresponding keto acid, converting the enzymebound pyridoxal phosphate to bound pyridoxamine phosphate (2). Other amino acids such as methionine sulfoxide, methionine sulfone, and alanine react much more slowly with the enzyme, but the reaction itself appears t...
متن کاملElevation of y=Aminobutyric Acid in Brain: Selective Inhibition of y-Aminobutyric-a-ketoglutaric Acid Transaminase*
The quantitative measurement of amino acids in different areas of the central nervous system has shown that a progressive increase takes place in levels of y-aminobutyric acid during development (2, 3), and that the concentration of this amino acid in adult brain is relatively constant under a variety of physiological stresses. y-Aminobutyric acid is synthesized by glutamic acid decarboxylase, ...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1960
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.72.2_507